The authors here present a proposed framework for the application of a strategy to manage human talent toward achieving research excellence in Palestinian universities in light of knowledge society. The authors adopt a descriptive-analytical method, and use a wide survey to achieve their research goals. The sample used consists of 110 heads of academic departments working in Palestinian universities in the Gaza Strip. The results shows a statistically significant correlation between the degree of application of a human talent management strategy and the achievement of research excellence; between the degree of application of a human talent management strategy and the creation of a knowledge society; and between the creation of a knowledge society and the achievement of research excellence.